Estudo do valor prognóstico do Ki-67 em adenocarcinomas colorretais e sua correlação com parámetros clínico-patológicos.

Study of the prognosis value of Ki-67 in colorectal adenocarcinomas and its correlation with clinicopathological parameters

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Ana Alves
Javier Muñoz

Resumen

Estudar o valor prognóstico do Ki-67 em Adenocarcinomas Colorretais, correlacionando-o com diferentes parámetros clínico-patológicos. Trinta cinco pacientes com adenocarcinoma colorretal foram submetidos a resseção cirúrgica do respetivo tumor e sujeitos a um follow-up pós-operatório de 10 anos. Observou-se correlação estatisticamente significativa entre a “expressão imunohistoquímica do Ki-67” e o “prognóstico dos pacientes” (p < 0,05),
mas não com a “localização” e o “grau de diferenciação tumoral” (p > 0,05). Aos 10 anos a sobrevivéncia foi de 62,9%. A determinação da correlação do Ki-67 com o “grau de diferenciação” e “localização” dos Adenocarcinomas Colorretais tem- se mostrado, na maioria dos estudos, não estatisticamente significativa. Contudo, este marcador parece apresentar valor prognóstico.

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